Mitochondria-Targeted Polyamidoamine Dendrimer-Curcumin Construct for Hepatocellular Cancer Treatment.
Kianamiri S, Dinari A, Sadeghizadeh M, Rezaei M, Daraei B, Bahsoun NE, Nomani A.
Kianamiri S, et al.
Mol Pharm. 2020 Dec 7;17(12):4483-4498. doi: 10.1021/acs.molpharmaceut.0c00566. Epub 2020 Nov 18.
Mol Pharm. 2020.
PMID: 33205974
Our findings showed that the targeted-dendrimeric curcumin (TDC) could successfully deliver and colocalize the drug to the mitochondria of the cancer cells, and selectively induce a potent apoptosis and cell cycle arrest at G2/M. Moreover, at a low curcumin dose of less th …
Our findings showed that the targeted-dendrimeric curcumin (TDC) could successfully deliver and colocalize the drug to the mitochondria of t …